Forced virus evolution reveals functional crosstalk between the disulfide bonded region and membrane proximal ectodomain region of HIV-1 gp41

BACKGROUND: The disulfide-bonded region (DSR) of HIV-1 gp41 mediates association with gp120 and plays a role in transmission of receptor-induced conformational changes in gp120 to gp41 that activate membrane fusion function. In this study, forced viral evolution of a DSR mutant that sheds gp120 was...

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Detalles Bibliográficos
Autores principales: Khasawneh, Ashraf I, Laumaea, Annemarie, Harrison, David N, Bellamy-McIntyre, Anna K, Drummer, Heidi E, Poumbourios, Pantelis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643854/
https://www.ncbi.nlm.nih.gov/pubmed/23618462
http://dx.doi.org/10.1186/1742-4690-10-44

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643854/
https://www.ncbi.nlm.nih.gov/pubmed/23618462
http://dx.doi.org/10.1186/1742-4690-10-44

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