The Progestin-Only Contraceptive Medroxyprogesterone Acetate, but Not Norethisterone Acetate, Enhances HIV-1 Vpr-Mediated Apoptosis in Human CD4(+) T Cells through the Glucocorticoid Receptor

The glucocorticoid receptor (GR) regulates several physiological functions, including immune function and apoptosis. The HIV-1 virus accessory protein, viral protein R (Vpr), can modulate the transcriptional response of the GR. Glucocorticoids (GCs) and Vpr have been reported to induce apoptosis in...

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Detalles Bibliográficos
Autores principales: Tomasicchio, Michele, Avenant, Chanel, Du Toit, Andrea, Ray, Roslyn M., Hapgood, Janet P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643923/
https://www.ncbi.nlm.nih.gov/pubmed/23658782
http://dx.doi.org/10.1371/journal.pone.0062895

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3643923/
https://www.ncbi.nlm.nih.gov/pubmed/23658782
http://dx.doi.org/10.1371/journal.pone.0062895

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