Structural basis of protein phosphatase 2A stable latency

The catalytic subunit of protein phosphatase 2A (PP2Ac) is stabilized in a latent form by α4, a regulatory protein essential for cell survival and biogenesis of all PP2A complexes. Here we report the structure of α4 bound to the N-terminal fragment of PP2Ac. This structure suggests that α4 binding t...

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Detalles Bibliográficos
Autores principales: Jiang, Li, Stanevich, Vitali, Satyshur, Kenneth A, Kong, Mei, Watkins, Guy R., Wadzinski, Brian E., Sengupta, Rituparna, Xing, Yongna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644067/
https://www.ncbi.nlm.nih.gov/pubmed/23591866
http://dx.doi.org/10.1038/ncomms2663

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644067/
https://www.ncbi.nlm.nih.gov/pubmed/23591866
http://dx.doi.org/10.1038/ncomms2663

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