Association between Gαi2 and ELMO1/Dock180 connects chemokine signalling with Rac activation and metastasis

The chemokine CXCL12 and its G-protein-coupled receptor CXCR4 control the migration, invasiveness and metastasis of breast cancer cells. Binding of CXCL12 to CXCR4 triggers activation of heterotrimeric Gi proteins that regulate actin polymerization and migration. However, the pathways linking chemok...

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Detalles Bibliográficos
Autores principales: Li, Hongyan, Yang, Lei, Fu, Hui, Yan, Jianshe, Wang, Ying, Guo, Hua, Hao, Xishan, Xu, Xuehua, Jin, Tian, Zhang, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644068/
https://www.ncbi.nlm.nih.gov/pubmed/23591873
http://dx.doi.org/10.1038/ncomms2680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644068/
https://www.ncbi.nlm.nih.gov/pubmed/23591873
http://dx.doi.org/10.1038/ncomms2680

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