Prostaglandin E(2) promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase

T helper 1 (Th1) cells have critical roles in various autoimmune and proinflammatory diseases. cAMP has long been believed to act as a suppressor of IFN-γ production and Th1 cell-mediated immune inflammation. Here we show that cAMP actively promotes Th1 differentiation by inducing gene expression of...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Chengcan, Hirata, Takako, Soontrapa, Kitipong, Ma, Xiaojun, Takemori, Hiroshi, Narumiya, Shuh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644078/
https://www.ncbi.nlm.nih.gov/pubmed/23575689
http://dx.doi.org/10.1038/ncomms2684

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644078/
https://www.ncbi.nlm.nih.gov/pubmed/23575689
http://dx.doi.org/10.1038/ncomms2684

Ejemplares similares