Cargando…

Prostaglandin E(2) promotes Th1 differentiation via synergistic amplification of IL-12 signalling by cAMP and PI3-kinase

T helper 1 (Th1) cells have critical roles in various autoimmune and proinflammatory diseases. cAMP has long been believed to act as a suppressor of IFN-γ production and Th1 cell-mediated immune inflammation. Here we show that cAMP actively promotes Th1 differentiation by inducing gene expression of...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yao, Chengcan, Hirata, Takako, Soontrapa, Kitipong, Ma, Xiaojun, Takemori, Hiroshi, Narumiya, Shuh
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644078/ https://www.ncbi.nlm.nih.gov/pubmed/23575689 http://dx.doi.org/10.1038/ncomms2684

Ejemplares similares

Prostaglandin‐cytokine crosstalk in chronic inflammation
por: Yao, Chengcan, et al.
Publicado: (2018)

Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1
por: Nagamachi, Miyako, et al.
Publicado: (2007)

T cell–intrinsic prostaglandin E(2)-EP2/EP4 signaling is critical in pathogenic T(H)17 cell–driven inflammation
por: Lee, Jinju, et al.
Publicado: (2019)

Prostaglandin E(2) directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF‐β signalling
por: Goepp, Marie, et al.
Publicado: (2021)

Prostaglandin Receptor Signaling in Disease
por: Matsuoka, Toshiyuki, et al.
Publicado: (2007)

Prostaglandin E(2)-EP2 signaling as a node of chronic inflammation in the colon tumor microenvironment
por: Aoki, Tomohiro, et al.
Publicado: (2017)

The induction of cyclooxygenase-2 in IL-1beta-treated endothelial cells is inhibited by prostaglandin E2 through cAMP.
por: Akarasereenont, P, et al.
Publicado: (1999)

Role of cAMP in the promotion of colorectal cancer cell growth by Prostaglandin E2
por: Löffler, Ivonne, et al.
Publicado: (2008)

Role of the Prostaglandin E(2) EP1 Receptor in Traumatic Brain Injury
por: Glushakov, Alexander V., et al.
Publicado: (2014)

Synergistic Radioprotection by Gamma-Tocotrienol and Pentoxifylline: Role of cAMP Signaling
por: Kulkarni, Shilpa, et al.
Publicado: (2013)

Inhibition of DYRK1B suppresses inflammation in allergic contact dermatitis model and Th1/Th17 immune response
por: Wongchang, Thamrong, et al.
Publicado: (2023)

EP(2) and EP(4) receptors on muscularis resident macrophages mediate LPS-induced intestinal dysmotility via iNOS upregulation through cAMP/ERK signals
por: Tajima, Tsuyoshi, et al.
Publicado: (2012)

Prostaglandin D2 signaling in dendritic cells is critical for the development of EAE
por: Zheng, Jian, et al.
Publicado: (2020)

Prostacyclin-IP signaling and prostaglandin E(2)-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis
por: Honda, Tetsuya, et al.
Publicado: (2006)

Biomechanical forces promote blood development through prostaglandin E(2) and the cAMP–PKA signaling axis
por: Diaz, Miguel F., et al.
Publicado: (2015)

Signaling of Prostaglandin E Receptors, EP3 and EP4 Facilitates Wound Healing and Lymphangiogenesis with Enhanced Recruitment of M2 Macrophages in Mice
por: Hosono, Kanako, et al.
Publicado: (2016)

Prostaglandin F(2α) FP receptor antagonist improves outcomes after experimental traumatic brain injury
por: Glushakov, Alexander V, et al.
Publicado: (2013)

Multiple Facets of cAMP Signalling and Physiological Impact: cAMP Compartmentalization in the Lung
por: Oldenburger, Anouk, et al.
Publicado: (2012)

Acetylsalicylic acid (ASA) protects the prostaglandin-cAMP-system of human hypernephroma cells against irradiation-induced alterations.
por: Li, S. R., et al.
Publicado: (1993)

IL-4 induces cAMP and cGMP in human monocytic cells
por: Dugas, B., et al.
Publicado: (1995)

cAMP crosses junctions
por: Bashyam, Hema
Publicado: (2007)

Mitochondrial cAMP signaling
por: Zhang, Fan, et al.
Publicado: (2016)

PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway
por: Kong, Xiangyu, et al.
Publicado: (2019)

Sensitization of TRPV1 by EP(1 )and IP reveals peripheral nociceptive mechanism of prostaglandins
por: Moriyama, Tomoko, et al.
Publicado: (2005)

Roles of Toll-like receptor 2/4, monoacylglycerol lipase, and cyclooxygenase in social defeat stress-induced prostaglandin E(2) synthesis in the brain and their behavioral relevance
por: Nie, Xiang, et al.
Publicado: (2019)

Non‐steroidal anti‐inflammatory drugs, prostaglandins, and COVID‐19
por: Robb, Calum T., et al.
Publicado: (2020)

Prostaglandin E(2)-EP3 Axis in Fine-Tuning Excessive Skin Inflammation by Restricting Dendritic Cell Functions
por: Shiraishi, Noriko, et al.
Publicado: (2013)

Cytokine-induced killer cells: A novel treatment for allergic airway inflammation
por: Pluangnooch, Panwadee, et al.
Publicado: (2017)

Immunosuppressive effect of hispidulin in allergic contact dermatitis
por: Thitilertdecha, Premrutai, et al.
Publicado: (2019)

Bach2–Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop
por: Kuwahara, Makoto, et al.
Publicado: (2016)

Cyclic 3', 5'-AMP relay in dictyostelium discoideum. IV. Recovery of the cAMP signaling response after adaptation to cAMP
por: Dinauer, M, et al.
Publicado: (1980)

Cyclic 3', 5'-AMP relay dictyostelium discoideum. V. Adaptation of the cAMP signaling response during cAMP stimulation
por: Dinauer, M, et al.
Publicado: (1980)

Suppression of Virulence of Toxigenic Vibrio cholerae by Anethole through the Cyclic AMP (cAMP)-cAMP Receptor Protein Signaling System
por: Zahid, M. Shamim Hasan, et al.
Publicado: (2015)

cAMP and c-di-GMP synergistically support biofilm maintenance through the direct interaction of their effectors
por: Liu, Cong, et al.
Publicado: (2022)

Imaging cAMP nanodomains in the heart
por: Chao, Ying-Chi, et al.
Publicado: (2019)

cAMP is an allosteric modulator of DNA-binding specificity in the cAMP receptor protein from Mycobacterium tuberculosis
por: Gárate, Fernanda, et al.
Publicado: (2021)

An Improved Genetically Encoded Fluorescent cAMP Indicator for Sensitive cAMP Imaging and Fast Drug Screening
por: Liu, Wenfeng, et al.
Publicado: (2022)

Cyclic 3',5'-AMP relay in Dictyostelium discoideum III. The relationship of cAMP synthesis and secretion during the cAMP signaling response
Publicado: (1980)

Direct regulation of the natural competence regulator gene tfoX by cyclic AMP (cAMP) and cAMP receptor protein (CRP) in Vibrios
por: Wu, Rui, et al.
Publicado: (2015)

Regulation of Inositol 1,4,5-Trisphosphate Receptors by cAMP Independent of cAMP-dependent Protein Kinase
por: Tovey, Stephen C., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_sano6tva84mt4eamkepkvh1u7j