Ligand binding and aggregation of pathogenic SOD1

Mutations in the gene encoding Cu/Zn superoxide dismutase-1 cause amyotrophic lateral sclerosis. Superoxide dismutase-1 mutations decrease protein stability and promote aggregation. The mutant monomer is thought to be an intermediate in the pathway from the superoxide dismutase-1 dimer to aggregate....

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Detalles Bibliográficos
Autores principales: Wright, Gareth S.A., Antonyuk, Svetlana V., Kershaw, Neil M., Strange, Richard W., Samar Hasnain, S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644087/
https://www.ncbi.nlm.nih.gov/pubmed/23612299
http://dx.doi.org/10.1038/ncomms2750

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644087/
https://www.ncbi.nlm.nih.gov/pubmed/23612299
http://dx.doi.org/10.1038/ncomms2750

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