Cargando…

Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in Merkel cell carcinoma

Merkel cell carcinoma (MCC) is an aggressive, polyomavirus-linked skin cancer. While CD8 lymphocyte infiltration into the tumor is strongly correlated with improved survival, these cells are absent or sparse in most MCCs. We investigated whether specific mechanisms of T-cell migration may be commonl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Afanasiev, Olga K., Nagase, Kotaro, Simonson, William, Vandeven, Natalie, Blom, Astrid, Koelle, David M., Clark, Rachael, Nghiem, Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644376/ https://www.ncbi.nlm.nih.gov/pubmed/23353989 http://dx.doi.org/10.1038/jid.2013.36

Ejemplares similares

Complete Spontaneous Regression of Merkel Cell Carcinoma Metastatic to the Liver: Did Lifestyle Modifications and Dietary Supplements Play a Role?
por: Vandeven, Natalie, et al.
Publicado: (2012)

Diagnostic Biopsy Does Not Commonly Induce Intratumoral CD8 T Cell Infiltration in Merkel Cell Carcinoma
por: Koba, Shinichi, et al.
Publicado: (2012)

Correction: Diagnostic Biopsy Does Not Commonly Induce Intratumoral CD8 T Cell Infiltration in Merkel Cell Carcinoma
por: Koba, Shinichi, et al.
Publicado: (2012)

Systemic immune suppression as a stage-independent predictor of diminished Merkel cell carcinoma-specific survival
por: Paulson, Kelly G., et al.
Publicado: (2012)

Merkel Cell Polyoma Viral Load and Intratumoral CD8+ Lymphocyte Infiltration Predict Overall Survival in Patients With Merkel Cell Carcinoma
por: von der Grün, Jens, et al.
Publicado: (2019)

LAMP1 targeting of the large T antigen of Merkel cell polyomavirus results in potent CD4 T cell responses and tumor inhibition
por: Buchta Rosean, Claire, et al.
Publicado: (2023)

Clinical Benefit from Tyrosine Kinase Inhibitors in Metastatic Merkel Cell Carcinoma: A Case Series of 5 Patients
por: Tarabadkar, Erica S., et al.
Publicado: (2018)

CD200 Expression in Neuroendocrine Neoplasms
por: Love, Jason E, et al.
Publicado: (2017)

Tumor-infiltrating lymphocytes and outcome in Merkel cell carcinoma, a virus-associated cancer
por: Sihto, Harri, et al.
Publicado: (2012)

Single-fraction radiation therapy in patients with metastatic Merkel cell carcinoma
por: Iyer, Jayasri G, et al.
Publicado: (2015)

Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma
por: Iyer, Jayasri G., et al.
Publicado: (2016)

Tumor Ulceration, Reduced Infiltration of CD8-Lymphocytes, High Neutrophil-to-CD8-Lymphocyte Ratio and Absence of MC Virus are Negative Prognostic Markers for Patients with Merkel Cell Carcinoma
por: Naseri, Simon, et al.
Publicado: (2020)

Transcriptional and functional analyses of neoantigen-specific CD4 T cells during a profound response to anti-PD-L1 in metastatic Merkel cell carcinoma
por: Church, Candice, et al.
Publicado: (2022)

Tetraspanin CD53 Promotes Lymphocyte Recirculation by Stabilizing L-Selectin Surface Expression
por: Demaria, Maria C., et al.
Publicado: (2020)

Association of Merkel Cell Polyomavirus–Specific Antibodies With Merkel Cell Carcinoma
por: Carter, Joseph J., et al.
Publicado: (2009)

Mutational landscape of MCPyV-positive and MCPyV-negative Merkel cell carcinomas with implications for immunotherapy
por: Goh, Gerald, et al.
Publicado: (2015)

The Cutaneous Lymphocyte Antigen Is an Essential Component of the L-selectin Ligand Induced on Human Vascular Endothelial Cells
por: Tu, LiLi, et al.
Publicado: (1999)

Merkel cell polyomavirus-specific immune responses in patients with Merkel cell carcinoma receiving anti-PD-1 therapy
por: Miller, Natalie J., et al.
Publicado: (2018)

Merkel Cell Polyomavirus and Merkel Cell Carcinoma, France
por: Foulongne, Vincent, et al.
Publicado: (2008)

The Distribution of Activation Markers and Selectins on Peripheral T Lymphocytes in Preeclampsia
por: Bajnok, Anna, et al.
Publicado: (2017)

Does a new polyomavirus contribute to Merkel cell carcinoma?
por: Garneski, Kelly M, et al.
Publicado: (2008)

Interactions of human alpha/beta and gamma/delta T lymphocyte subsets in shear flow with E-selectin and P-selectin
Publicado: (1996)

L-Selectin Ligands That Are O-glycoprotease Resistant and Distinct from MECA-79 Antigen are Sufficient for Tethering and Rolling of Lymphocytes on Human High Endothelial Venules
por: Clark, Rachael A., et al.
Publicado: (1998)

P-selectin and vascular cell adhesion molecule 1 mediate rolling and arrest, respectively, of CD4+ T lymphocytes on tumor necrosis factor alpha-activated vascular endothelium under flow
Publicado: (1995)

Characterisation of Plasmodium falciparum populations selected on the human endothelial receptors P-selectin, E-selectin, CD9 and CD151
por: Metwally, Nahla Galal, et al.
Publicado: (2017)

Discovery of CD8 T cell epitopes in Merkel cell polyomavirus through combinatorial encoding with MHC multimers
por: Lyngaa, Rikke, et al.
Publicado: (2013)

The Shedding of CD62L (L-Selectin) Regulates the Acquisition of Lytic Activity in Human Tumor Reactive T Lymphocytes
por: Yang, Shicheng, et al.
Publicado: (2011)

Nitric oxide-producing myeloid-derived suppressor cells inhibit vascular E- selectin expression in human squamous cell carcinomas
por: Gehad, Ahmed, et al.
Publicado: (2012)

Postoperative radiation therapy is associated with a reduced risk of local recurrence among low risk Merkel cell carcinomas of the head and neck
por: Takagishi, Seesha R., et al.
Publicado: (2016)

Vascular Adhesion Protein 1 (VAP-1) Mediates Lymphocyte Subtype-specific, Selectin-independent Recognition of Vascular Endothelium in Human Lymph Nodes
por: Salmi, Marko, et al.
Publicado: (1997)

Prognostic Role of Tumoral PD-L1 and IDO1 Expression, and Intratumoral CD8+ and FoxP3+ Lymphocyte Infiltrates in 132 Primary Cutaneous Merkel Cell Carcinomas
por: Donizy, Piotr, et al.
Publicado: (2021)

Clinical-Pathological Evaluation and Prognostic Analysis of 228 Merkel Cell Carcinomas Focusing on Tumor-Infiltrating Lymphocytes, MCPYV Infection and ALK Expression
por: Santoro, Federica, et al.
Publicado: (2022)

P29. T-cell responses to oncogenic Merkel cell polyomavirus proteins distinguish Merkel cell carcinoma patients from healthy donors
por: Lyngaa, L, et al.
Publicado: (2014)

Merkel cell carcinoma mimicking transformed chronic lymphocytic leukemia/small lymphocytic lymphoma
por: Bah, Ismael, et al.
Publicado: (2019)

Travel burden associated with rare cancers: The example of Merkel cell carcinoma
por: Jain, Rahul, et al.
Publicado: (2019)

Insights into anti-tumor immunity via the polyomavirus shared across human Merkel cell carcinomas
por: Jani, Saumya, et al.
Publicado: (2023)

Chronic lymphocytic leukaemia patients have a high risk of Merkel-cell polyomavirus DNA-positive Merkel-cell carcinoma
por: Koljonen, V, et al.
Publicado: (2009)

P-Selectin Glycoprotein Ligand 1 (Psgl-1) Is a Physiological Ligand for E-Selectin in Mediating T Helper 1 Lymphocyte Migration
por: Hirata, Takako, et al.
Publicado: (2000)

Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells
por: Clark, Rachael A., et al.
Publicado: (2008)

First-line avelumab in a cohort of 116 patients with metastatic Merkel cell carcinoma (JAVELIN Merkel 200): primary and biomarker analyses of a phase II study
por: D'Angelo, Sandra P, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_3amcavl9qoo05oqtvvcfe1csm3