A novel proteasome inhibitor acting in mitochondrial dysfunction, ER stress and ROS production

In cancer-treatment, potentially therapeutic drugs trigger their effects through apoptotic mechanisms. Generally, cell response is manifested by Bcl-2 family protein regulation, the impairment of mitochondrial functions, and ROS production. Notwithstanding, several drugs operate through proteasome i...

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Detalles Bibliográficos
Autores principales: Maria, Durvanei Augusto, de Souza, Jean Gabriel, Morais, Katia L. P., Berra, Carolina Maria, Zampolli, Hamilton de Campos, Demasi, Marilene, Simons, Simone Michaela, de Freitas Saito, Renata, Chammas, Roger, Chudzinski-Tavassi, Ana Marisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Preclinical Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644403/
https://www.ncbi.nlm.nih.gov/pubmed/22975862
http://dx.doi.org/10.1007/s10637-012-9871-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644403/
https://www.ncbi.nlm.nih.gov/pubmed/22975862
http://dx.doi.org/10.1007/s10637-012-9871-1

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