Phase I study of enzastaurin and bevacizumab in patients with advanced cancer: safety, efficacy and pharmacokinetics

Purpose Given distinct mechanism of actions of enzastaurin and bevacizumab, preclinical studies suggest enhanced antitumor activity in combination. This phase I study assessed the combination’s safety and efficacy. Patients and methods Six advanced cancer patients could be enrolled in each of 11 coh...

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Detalles Bibliográficos
Autores principales: Nwankwo, Nwabundo, Zhang, Zhe, Wang, Ting, Collins, Connie, Resta, Lee, Ermisch, Sabine, Day, Jeannette, Decker, Rodney, Kornberg, Lori, Nicol, Steven, Thornton, Donald, Armstrong, Deborah K., Carducci, Michael A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2012
Materias:
Phase I Studies
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644404/
https://www.ncbi.nlm.nih.gov/pubmed/22766773
http://dx.doi.org/10.1007/s10637-012-9850-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644404/
https://www.ncbi.nlm.nih.gov/pubmed/22766773
http://dx.doi.org/10.1007/s10637-012-9850-6

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