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Parkinson’s disease-associated mutations in DJ-1 modulate its dimerization in living cells
Mutations in the protein DJ-1 cause recessive forms of early onset familial Parkinson’s disease (PD). To date, most of the causative mutations studied destabilize formation of DJ-1 homodimers, which appears to be closely linked to its normal function in oxidative stress and other cellular processes....
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer-Verlag
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644405/ https://www.ncbi.nlm.nih.gov/pubmed/23183826 http://dx.doi.org/10.1007/s00109-012-0976-y |