SPARC-induced increase in glioma matrix and decrease in vascularity are associated with reduced VEGF expression and secretion

Glioblastomas are heterogeneous tumors displaying regions of necrosis, proliferation, angiogenesis, apoptosis and invasion. SPARC, a matricellular protein that negatively regulates angiogenesis and cell proliferation, but enhances cell deadhesion from matrix, is upregulated in gliomas (Grades II–IV)...

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Detalles Bibliográficos
Autores principales: Yunker, Christopher K, Golembieski, William, Lemke, Nancy, Schultz, Chad R, Cazacu, Simona, Brodie, Chaya, Rempel, Sandra A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Subscription Services, Inc., A Wiley Company 2008
Materias:
Cancer Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644882/
https://www.ncbi.nlm.nih.gov/pubmed/18350569
http://dx.doi.org/10.1002/ijc.23450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644882/
https://www.ncbi.nlm.nih.gov/pubmed/18350569
http://dx.doi.org/10.1002/ijc.23450

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