A Novel Function of Novobiocin: Disrupting the Interaction of HIF 1α and p300/CBP through Direct Binding to the HIF1α C-Terminal Activation Domain

Hypoxia-inducible factor 1α (HIF1α) is an important cellular survival protein under hypoxic conditions, regulating the cellular response to low oxygen tension via recruitment of a transcriptional co-activator, p300/CBP. p300/CBP induces expression of multiple genes involved in cell survival, prolife...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Donglu, Zhang, Rui, Zhao, Rui, Chen, Guang, Cai, Yong, Jin, Jingji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646014/
https://www.ncbi.nlm.nih.gov/pubmed/23671581
http://dx.doi.org/10.1371/journal.pone.0062014

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646014/
https://www.ncbi.nlm.nih.gov/pubmed/23671581
http://dx.doi.org/10.1371/journal.pone.0062014

Ejemplares similares