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A Novel Function of Novobiocin: Disrupting the Interaction of HIF 1α and p300/CBP through Direct Binding to the HIF1α C-Terminal Activation Domain

Hypoxia-inducible factor 1α (HIF1α) is an important cellular survival protein under hypoxic conditions, regulating the cellular response to low oxygen tension via recruitment of a transcriptional co-activator, p300/CBP. p300/CBP induces expression of multiple genes involved in cell survival, prolife...

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Detalles Bibliográficos
Autores principales:	Wu, Donglu, Zhang, Rui, Zhao, Rui, Chen, Guang, Cai, Yong, Jin, Jingji
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646014/ https://www.ncbi.nlm.nih.gov/pubmed/23671581 http://dx.doi.org/10.1371/journal.pone.0062014

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