Attenuating homologous recombination stimulates an AID-induced antileukemic effect

Activation-induced cytidine deaminase (AID) is critical in normal B cells to initiate somatic hypermutation and immunoglobulin class switch recombination. Accumulating evidence suggests that AID is also prooncogenic, inducing cancer-promoting mutations or chromosome rearrangements. In this context,...

Descripción completa

Detalles Bibliográficos
Autores principales: Lamont, Kristin R., Hasham, Muneer G., Donghia, Nina M., Branca, Jane, Chavaree, Margaret, Chase, Betsy, Breggia, Anne, Hedlund, Jacquelyn, Emery, Ivette, Cavallo, Francesca, Jasin, Maria, Rüter, Jens, Mills, Kevin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646491/
https://www.ncbi.nlm.nih.gov/pubmed/23589568
http://dx.doi.org/10.1084/jem.20121258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646491/
https://www.ncbi.nlm.nih.gov/pubmed/23589568
http://dx.doi.org/10.1084/jem.20121258

Ejemplares similares