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Attenuating homologous recombination stimulates an AID-induced antileukemic effect
Activation-induced cytidine deaminase (AID) is critical in normal B cells to initiate somatic hypermutation and immunoglobulin class switch recombination. Accumulating evidence suggests that AID is also prooncogenic, inducing cancer-promoting mutations or chromosome rearrangements. In this context,...
Autores principales: | Lamont, Kristin R., Hasham, Muneer G., Donghia, Nina M., Branca, Jane, Chavaree, Margaret, Chase, Betsy, Breggia, Anne, Hedlund, Jacquelyn, Emery, Ivette, Cavallo, Francesca, Jasin, Maria, Rüter, Jens, Mills, Kevin D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646491/ https://www.ncbi.nlm.nih.gov/pubmed/23589568 http://dx.doi.org/10.1084/jem.20121258 |
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