Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance

The (histone) deacetylase Sirt1 is a mediator of genomic and epigenetic maintenance, both of which are critical aspects of stem cell homeostasis and tightly linked to their functional decline in aging and disease. We show that Sirt1 ablation in adult hematopoietic stem and progenitor cells (HSPCs) p...

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Detalles Bibliográficos
Autores principales: Singh, Satyendra K., Williams, Carrie A., Klarmann, Kimberly, Burkett, Sandra S., Keller, Jonathan R., Oberdoerffer, Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646499/
https://www.ncbi.nlm.nih.gov/pubmed/23630229
http://dx.doi.org/10.1084/jem.20121608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646499/
https://www.ncbi.nlm.nih.gov/pubmed/23630229
http://dx.doi.org/10.1084/jem.20121608

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