Cargando…

Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance

The (histone) deacetylase Sirt1 is a mediator of genomic and epigenetic maintenance, both of which are critical aspects of stem cell homeostasis and tightly linked to their functional decline in aging and disease. We show that Sirt1 ablation in adult hematopoietic stem and progenitor cells (HSPCs) p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Satyendra K., Williams, Carrie A., Klarmann, Kimberly, Burkett, Sandra S., Keller, Jonathan R., Oberdoerffer, Philipp
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2013
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646499/ https://www.ncbi.nlm.nih.gov/pubmed/23630229 http://dx.doi.org/10.1084/jem.20121608

Ejemplares similares

Epigenetic Memories in Hematopoietic Stem and Progenitor Cells
por: Aoyama, Kazumasa, et al.
Publicado: (2022)

RanBPM (RanBP9) regulates mouse c-Kit receptor level and is essential for normal development of bone marrow progenitor cells
por: Puverel, Sandrine, et al.
Publicado: (2016)

Replication Stress: A Lifetime of Epigenetic Change
por: Khurana, Simran, et al.
Publicado: (2015)

Stop relaxing: How DNA damage-induced chromatin compaction may affect epigenetic integrity and disease
por: Oberdoerffer, Philipp
Publicado: (2014)

C/EBPα Is Required for Long-Term Self-Renewal and Lineage Priming of Hematopoietic Stem Cells and for the Maintenance of Epigenetic Configurations in Multipotent Progenitors
por: Hasemann, Marie S., et al.
Publicado: (2014)

Isolation, Maintenance and Expansion of Adult Hematopoietic Stem/Progenitor Cells and Leukemic Stem Cells
por: Mayer, Isabella Maria, et al.
Publicado: (2022)

Hematopoietic Stem and Progenitor Cells in Inflammation and Allergy
por: Fischer, Kimberly D., et al.
Publicado: (2013)

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells
por: Rimmelé, Pauline, et al.
Publicado: (2014)

Requirements for survivin in terminal differentiation of erythroid cells and maintenance of hematopoietic stem and progenitor cells
por: Leung, Cindy G., et al.
Publicado: (2007)

CXCL12 Production by Early Mesenchymal Progenitors is Required for Hematopoietic Stem Cell Maintenance
por: Greenbaum, Adam, et al.
Publicado: (2013)

Lipoprotein lipase regulates hematopoietic stem progenitor cell maintenance through DHA supply
por: Liu, Chao, et al.
Publicado: (2018)

Myh9 Plays an Essential Role in the Survival and Maintenance of Hematopoietic Stem/Progenitor Cells
por: An, Quanming, et al.
Publicado: (2022)

Glia maturation factor-γ is required for initiation and maintenance of hematopoietic stem and progenitor cells
por: Li, Honghu, et al.
Publicado: (2023)

Hematopoietic Stem and Progenitor Cell Maintenance and Multiple Lineage Differentiation Is an Integral Function of NFATc1
por: Barahona de Brito, Carlotta, et al.
Publicado: (2022)

Aberrant epigenetic regulators control expansion of human CD34+ hematopoietic stem/progenitor cells
por: Faridi, Farnaz, et al.
Publicado: (2013)

Synergistic Integration of Mesenchymal Stem Cells and Hydrostatic Pressure in the Expansion and Maintenance of Human Hematopoietic/Progenitor Cells
por: Kang, Yun Gyeong, et al.
Publicado: (2018)

Control of Hematopoietic Stem and Progenitor Cell Function through Epigenetic Regulation of Energy Metabolism and Genome Integrity
por: Yang, Zhenhua, et al.
Publicado: (2019)

Loss of Angiopoietin-like 7 diminishes the regeneration capacity of hematopoietic stem and progenitor cells
por: Xiao, Yiren, et al.
Publicado: (2015)

ID2 and HIF-1α collaborate to protect quiescent hematopoietic stem cells from activation, differentiation, and exhaustion
por: Jakubison, Brad L., et al.
Publicado: (2022)

The SIRT1 Deacetylase Suppresses Intestinal Tumorigenesis and Colon Cancer Growth
por: Firestein, Ron, et al.
Publicado: (2008)

Epigenetic Profiling of PTPN11 Mutant JMML Hematopoietic Stem and Progenitor Cells Reveals an Aberrant Histone Landscape
por: Sinha, Roshani, et al.
Publicado: (2023)

Loss of SIRT1 inhibits hematopoietic stem cell aging and age-dependent mixed phenotype acute leukemia
por: Wang, Zhiqiang, et al.
Publicado: (2022)

Overexpression of GATA2 Enhances Development and Maintenance of Human Embryonic Stem Cell-Derived Hematopoietic Stem Cell-like Progenitors
por: Zhou, Ya, et al.
Publicado: (2019)

Loss of ASXL1 in the bone marrow niche dysregulates hematopoietic stem and progenitor cell fates
por: Zhang, Peng, et al.
Publicado: (2018)

Intermediate progenitor cells provide a transition between hematopoietic progenitors and their differentiated descendants
por: Spratford, Carrie M., et al.
Publicado: (2021)

Loss of Atg2b and Gskip Impairs the Maintenance of the Hematopoietic Stem Cell Pool Size
por: Sakai, Shun-suke, et al.
Publicado: (2022)

Epigenetic Regulation of Hematopoietic Stem Cells
por: Sharma, Shilpa, et al.
Publicado: (2016)

SIRT1-SIRT7 Expression in Patients with Lymphoproliferative Disorders Undergoing Hematopoietic Stem Cell Mobilization
por: Nowicki, Mateusz, et al.
Publicado: (2022)

A Method to Study the Epigenetic Chromatin States of Rare Hematopoietic Stem and Progenitor Cells; MiniChIP–Chip
por: Weishaupt, Holger, et al.
Publicado: (2010)

Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential
por: Lange, Lucas, et al.
Publicado: (2020)

Inducible Forward Programming of Human Pluripotent Stem Cells to Hemato-endothelial Progenitor Cells with Hematopoietic Progenitor Potential
por: Lange, Lucas, et al.
Publicado: (2019)

A critical role for Apc in hematopoietic stem and progenitor cell survival
por: Qian, Zhijian, et al.
Publicado: (2008)

Cell Adhesion-Mediated Actomyosin Assembly Regulates the Activity of Cubitus Interruptus for Hematopoietic Progenitor Maintenance in Drosophila
por: Sharma, Shiv Kumar, et al.
Publicado: (2019)

Progressive alterations in multipotent hematopoietic progenitors underlie lymphoid cell loss in aging
por: Young, Kira, et al.
Publicado: (2016)

S162: LOSS OF HEMATOPOIETIC PROGENITORS HETEROGENEITY IS AN ADVERSE PROGNOSTIC FACTOR IN MYELODYSPLASTIC SYNDROMES
por: Dussiau, Charles, et al.
Publicado: (2023)

Chemical Cocktail Induces Hematopoietic Reprogramming and Expands Hematopoietic Stem/Progenitor Cells
por: Zhou, Yi, et al.
Publicado: (2019)

Sirolimus augments hematopoietic stem and progenitor cell regeneration following hematopoietic insults
por: Lin, Zenghua, et al.
Publicado: (2020)

Epigenetic regulation of Atrophin1 by lysine-specific demethylase 1 is required for cortical progenitor maintenance
por: Zhang, Feng, et al.
Publicado: (2014)

Competition between hematopoietic stem and progenitor cells controls hematopoietic stem cell compartment size
por: Miao, Runfeng, et al.
Publicado: (2022)

Hematopoietic Stem and Progenitor Cells as Effectors in Innate Immunity
por: Granick, Jennifer L., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_tp2vpjh4u76qpcag61r6qbkkir