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Dampening the Signals Transduced through Hedgehog via MicroRNA miR-7 Facilitates Notch-Induced Tumourigenesis

Fine-tuned Notch and Hedgehog signalling pathways via attenuators and dampers have long been recognized as important mechanisms to ensure the proper size and differentiation of many organs and tissues. This notion is further supported by identification of mutations in these pathways in human cancer...

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Detalles Bibliográficos
Autores principales: Da Ros, Vanina G., Gutierrez-Perez, Irene, Ferres-Marco, Dolors, Dominguez, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646720/
https://www.ncbi.nlm.nih.gov/pubmed/23667323
http://dx.doi.org/10.1371/journal.pbio.1001554