Glioma Cell Death Induced by Irradiation or Alkylating Agent Chemotherapy Is Independent of the Intrinsic Ceramide Pathway

BACKGROUND/AIMS: Resistance to genotoxic therapy is a characteristic feature of glioma cells. Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and glucosylceramide synthase (GCS) catalyzes ceramide metabolism. Increased ceramide levels have been suggested to enhance chemotherapy-indu...

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Detalles Bibliográficos
Autores principales: Gramatzki, Dorothee, Herrmann, Caroline, Happold, Caroline, Becker, Katrin Anne, Gulbins, Erich, Weller, Michael, Tabatabai, Ghazaleh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646759/
https://www.ncbi.nlm.nih.gov/pubmed/23667632
http://dx.doi.org/10.1371/journal.pone.0063527

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646759/
https://www.ncbi.nlm.nih.gov/pubmed/23667632
http://dx.doi.org/10.1371/journal.pone.0063527

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