Poly-Ub-Substrate-Degradative Activity of 26S Proteasome Is Not Impaired in the Aging Rat Brain

Proteostasis is critical for the maintenance of life. In neuronal cells an imbalance between protein synthesis and degradation is thought to be involved in the pathogenesis of neurodegenerative diseases during aging. Partly, this seems to be due to a decrease in the activity of the ubiquitin-proteas...

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Detalles Bibliográficos
Autores principales: Giannini, Carolin, Kloß, Alexander, Gohlke, Sabrina, Mishto, Michele, Nicholson, Thomas P., Sheppard, Paul W., Kloetzel, Peter-Michael, Dahlmann, Burkhardt
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646778/
https://www.ncbi.nlm.nih.gov/pubmed/23667697
http://dx.doi.org/10.1371/journal.pone.0064042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646778/
https://www.ncbi.nlm.nih.gov/pubmed/23667697
http://dx.doi.org/10.1371/journal.pone.0064042

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