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Rapamycin Attenuates the Progression of Tau Pathology in P301S Tau Transgenic Mice

Altered autophagy contributes to the pathogenesis of Alzheimer’s disease and other tauopathies, for which curative treatment options are still lacking. We have recently shown that trehalose reduces tau pathology in a tauopathy mouse model by stimulation of autophagy. Here, we studied the effect of t...

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Detalles Bibliográficos
Autores principales: Ozcelik, Sefika, Fraser, Graham, Castets, Perrine, Schaeffer, Véronique, Skachokova, Zhiva, Breu, Karin, Clavaguera, Florence, Sinnreich, Michael, Kappos, Ludwig, Goedert, Michel, Tolnay, Markus, Winkler, David Theo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646815/
https://www.ncbi.nlm.nih.gov/pubmed/23667480
http://dx.doi.org/10.1371/journal.pone.0062459