Acridone Derivative 8a Induces Oxidative Stress-Mediated Apoptosis in CCRF-CEM Leukemia Cells: Application of Metabolomics in Mechanistic Studies of Antitumor Agents

A new acridone derivative, 2-aminoacetamido-10-(3, 5-dimethoxy)-benzyl-9(10H)-acridone hydrochloride (named 8a) synthesized in our lab shows potent antitumor activity, but the mechanism of action remains unclear. Herein, we report the use of an UPLC/Q-TOF MS metabolomic approach to study the effects...

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Detalles Bibliográficos
Autores principales: Wang, Yini, Gao, Dan, Chen, Zhe, Li, Shangfu, Gao, Chunmei, Cao, Deliang, Liu, Feng, Liu, Hongxia, Jiang, Yuyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646819/
https://www.ncbi.nlm.nih.gov/pubmed/23667640
http://dx.doi.org/10.1371/journal.pone.0063572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3646819/
https://www.ncbi.nlm.nih.gov/pubmed/23667640
http://dx.doi.org/10.1371/journal.pone.0063572

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