Enhancing Hit Identification in Mycobacterium tuberculosis Drug Discovery Using Validated Dual-Event Bayesian Models

High-throughput screening (HTS) in whole cells is widely pursued to find compounds active against Mycobacterium tuberculosis (Mtb) for further development towards new tuberculosis (TB) drugs. Hit rates from these screens, usually conducted at 10 to 25 µM concentrations, typically range from less tha...

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Detalles Bibliográficos
Autores principales: Ekins, Sean, Reynolds, Robert C., Franzblau, Scott G., Wan, Baojie, Freundlich, Joel S., Bunin, Barry A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647004/
https://www.ncbi.nlm.nih.gov/pubmed/23667592
http://dx.doi.org/10.1371/journal.pone.0063240

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647004/
https://www.ncbi.nlm.nih.gov/pubmed/23667592
http://dx.doi.org/10.1371/journal.pone.0063240

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