Comparison of responses of human melanoma cell lines to MEK and BRAF inhibitors

The NRAS and BRAF genes are frequently mutated in melanoma, suggesting that the NRAS-BRAF-MEK-ERK signaling pathway is an important target for therapy. Two classes of drugs, one targeting activated BRAF and one targeting MEK, are currently undergoing clinical evaluation. We have analysed the NRAS an...

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Detalles Bibliográficos
Autores principales: Stones, Clare J., Kim, Ji Eun, Joseph, Wayne R., Leung, Euphemia, Marshall, Elaine S., Finlay, Graeme J., Shelling, Andrew N., Baguley, Bruce C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2013
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647113/
https://www.ncbi.nlm.nih.gov/pubmed/23658559
http://dx.doi.org/10.3389/fgene.2013.00066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647113/
https://www.ncbi.nlm.nih.gov/pubmed/23658559
http://dx.doi.org/10.3389/fgene.2013.00066

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