Cargando…

Cathepsin‐L Ameliorates Cardiac Hypertrophy Through Activation of the Autophagy–Lysosomal Dependent Protein Processing Pathways

BACKGROUND: Autophagy is critical in the maintenance of cellular protein quality control, the final step of which involves the fusion of autophagosomes with lysosomes. Cathepsin‐L (CTSL) is a key member of the lysosomal protease family that is expressed in the murine and human heart, and it may play...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Mei, Ouzounian, Maral, de Couto, Geoffrey, Chen, Manyin, Yan, Ran, Fukuoka, Masahiro, Li, Guohua, Moon, Mark, Liu, Youan, Gramolini, Anthony, Wells, George J., Liu, Peter P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2013
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3647266/ https://www.ncbi.nlm.nih.gov/pubmed/23608608 http://dx.doi.org/10.1161/JAHA.113.000191

Ejemplares similares

Lysosomal Cathepsin D contributes to cell death during adipocyte hypertrophy
por: Eguchi, Akiko, et al.
Publicado: (2013)

Ceramide activates lysosomal cathepsin B and cathepsin D to attenuate autophagy and induces ER stress to suppress myeloid-derived suppressor cells
por: Liu, Feiyan, et al.
Publicado: (2016)

Sestrin 1 ameliorates cardiac hypertrophy via autophagy activation
por: Xue, Ruicong, et al.
Publicado: (2017)

Therapeutic potential of lysosomal cathepsins for neurodegenerative diseases
por: Prieto Huarcaya, Susy, et al.
Publicado: (2022)

Cathepsin Release from Lysosomes Promotes Endocytosis of Clostridium perfringens Iota-Toxin
por: Nagahama, Masahiro, et al.
Publicado: (2021)

Lysosomal elastase and cathepsin G in beige mice. Neutrophils of beige (Chediak-Higashi) mice selectively lack lysosomal elastase and cathepsin G
Publicado: (1986)

Corosolic acid ameliorates cardiac hypertrophy via regulating autophagy
por: Wang, Zhao-Peng, et al.
Publicado: (2019)

The Multifaceted Role of the Lysosomal Protease Cathepsins in Kidney Disease
por: Cocchiaro, Pasquale, et al.
Publicado: (2017)

The lysosomal protein cathepsin L is a progranulin protease
por: Lee, Chris W., et al.
Publicado: (2017)

The Key Role of Lysosomal Protease Cathepsins in Viral Infections
por: Scarcella, Melania, et al.
Publicado: (2022)

Suppression of calcium-sensing receptor ameliorates cardiac hypertrophy through inhibition of autophagy
por: LIU, LEI, et al.
Publicado: (2016)

Inhibition of autophagy blocks cathepsins–tBid–mitochondrial apoptotic signaling pathway via stabilization of lysosomal membrane in ischemic astrocytes
por: Zhou, Xian-Yong, et al.
Publicado: (2017)

TFEB ameliorates the impairment of the autophagy-lysosome pathway in neurons induced by doxorubicin
por: Moruno Manchon, Jose Felix, et al.
Publicado: (2016)

Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation
por: Zhang, Qianqian, et al.
Publicado: (2023)

Quinacrine-Induced Autophagy in Ovarian Cancer Triggers Cathepsin-L Mediated Lysosomal/Mitochondrial Membrane Permeabilization and Cell Death
por: Thirusangu, Prabhu, et al.
Publicado: (2021)

Internalization of Clostridium botulinum C2 Toxin Is Regulated by Cathepsin B Released from Lysosomes
por: Nagahama, Masahiro, et al.
Publicado: (2021)

Dynamic status of lysosomal cathepsin in bovine oocytes and preimplantation embryos
por: LI, Jianye, et al.
Publicado: (2019)

Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection
por: Qi, Xiaopeng, et al.
Publicado: (2016)

Lysosomal Hydrolase Cathepsin D Non-proteolytically Modulates Dendritic Morphology in Drosophila
por: Zhang, Ting, et al.
Publicado: (2020)

Lysosomal protease cathepsin D is a prognostic marker in endometrial cancer.
por: Lösch, A., et al.
Publicado: (1996)

Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins
por: Dev, Arvind, et al.
Publicado: (2013)

Erythropoietin-directed erythropoiesis depends on serpin inhibition of erythroblast lysosomal cathepsins
por: Dev, Arvind, et al.
Publicado: (2014)

Proteomic analysis of cathepsin B and L-deficient mouse brain lysosomes
por: Stahl, Sonja, et al.
Publicado: (2007)

Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
por: Pedram, Kayvon, et al.
Publicado: (2022)

Lysosome biology in autophagy
por: Yim, Willa Wen-You, et al.
Publicado: (2020)

Resveratrol Ameliorates Fibrosis in Rheumatoid Arthritis-Associated Interstitial Lung Disease via the Autophagy–Lysosome Pathway
por: Bao, Lanxin, et al.
Publicado: (2022)

Sophoricoside ameliorates cardiac hypertrophy by activating AMPK/mTORC1-mediated autophagy
por: Gao, Maomao, et al.
Publicado: (2020)

Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
por: Liang, Qiuli, et al.
Publicado: (2011)

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
por: Qiao, Liyan, et al.
Publicado: (2008)

Formaldehyde treatment of proteins enhances proteolytic degradation by the endo-lysosomal protease cathepsin S
por: Michiels, Thomas J. M., et al.
Publicado: (2020)

Effect of Lysosomal Cathepsin L on Proteolysis of Beef Myofibrillar Proteins In Vivo and In Vitro
por: Cui, Baowei, et al.
Publicado: (2022)

Impact of Enniatin B and Beauvericin on Lysosomal Cathepsin B Secretion and Apoptosis Induction
por: Aufy, Mohammed, et al.
Publicado: (2023)

PERK activation by SB202190 ameliorates amyloidogenesis via the TFEB-induced autophagy-lysosomal pathway
por: Do, Mihyang, et al.
Publicado: (2022)

Lysosomal Cathepsin A Plays a Significant Role in the Processing of Endogenous Bioactive Peptides
por: Timur, Zehra Kevser, et al.
Publicado: (2016)

Lysosomal cathepsin creates chimeric epitopes for diabetogenic CD4 T cells via transpeptidation
por: Reed, Brendan, et al.
Publicado: (2020)

A Transgenic Mouse Model of Eccentric Left Ventricular Hypertrophy With Preserved Ejection Fraction Exhibits Alterations in the Autophagy-Lysosomal Pathway
por: Wenzel, Kristin, et al.
Publicado: (2021)

Autophagy in lysosomal storage disorders
por: Lieberman, Andrew P., et al.
Publicado: (2012)

Autophagy and the Lysosomal System in Cancer
por: Kumar, Suresh, et al.
Publicado: (2021)

Significances of viable synergistic autophagy-associated cathepsin B and cathepsin D (CTSB/CTSD) as potential biomarkers for sudden cardiac death
por: Dai, Jialin, et al.
Publicado: (2021)

The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease
por: Monaco, Antonio, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_l4otmtmfp0tdserapkkj9o8oob