Structures of Coxsackievirus, Rhinovirus, and Poliovirus Polymerase Elongation Complexes Solved by Engineering RNA Mediated Crystal Contacts

RNA-dependent RNA polymerases play a vital role in the growth of RNA viruses where they are responsible for genome replication, but do so with rather low fidelity that allows for the rapid adaptation to different host cell environments. These polymerases are also a target for antiviral drug developm...

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Detalles Bibliográficos
Autores principales: Gong, Peng, Kortus, Matthew G., Nix, Jay C., Davis, Ralph E., Peersen, Olve B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648537/
https://www.ncbi.nlm.nih.gov/pubmed/23667424
http://dx.doi.org/10.1371/journal.pone.0060272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648537/
https://www.ncbi.nlm.nih.gov/pubmed/23667424
http://dx.doi.org/10.1371/journal.pone.0060272

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