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Signal Transduction Pathways in the Pentameric Ligand-Gated Ion Channels

The mechanisms of allosteric action within pentameric ligand-gated ion channels (pLGICs) remain to be determined. Using crystallography, site-directed mutagenesis, and two-electrode voltage clamp measurements, we identified two functionally relevant sites in the extracellular (EC) domain of the bact...

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Detalles Bibliográficos
Autores principales:	Mowrey, David, Chen, Qiang, Liang, Yuhe, Liang, Jie, Xu, Yan, Tang, Pei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648548/ https://www.ncbi.nlm.nih.gov/pubmed/23667707 http://dx.doi.org/10.1371/journal.pone.0064326

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