Withaferin A Effectively Targets Soluble Vimentin in the Glaucoma Filtration Surgical Model of Fibrosis

Withaferin A (WFA) is a natural product that binds to soluble forms of the type III intermediate filament (IF) vimentin. Currently, it is unknown under what pathophysiological contexts vimentin is druggable, as cytoskeltal vimentin-IFs are abundantly expressed. To investigate druggability of vimenti...

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Detalles Bibliográficos
Autores principales: Bargagna-Mohan, Paola, Deokule, Sunil P., Thompson, Kyle, Wizeman, John, Srinivasan, Cidambi, Vooturi, Sunil, Kompella, Uday B., Mohan, Royce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648549/
https://www.ncbi.nlm.nih.gov/pubmed/23667686
http://dx.doi.org/10.1371/journal.pone.0063881

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648549/
https://www.ncbi.nlm.nih.gov/pubmed/23667686
http://dx.doi.org/10.1371/journal.pone.0063881

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