Anthrax Toxin-Mediated Delivery of the Pseudomonas Exotoxin A Enzymatic Domain to the Cytosol of Tumor Cells via Cleavable Ubiquitin Fusions

Anthrax toxin proteins from Bacillus anthracis constitute a highly efficient system for delivering cytotoxic enzymes to the cytosol of tumor cells. However, exogenous proteins delivered to the cytosol of cells are subject to ubiquitination on lysines and proteasomal degradation, which limit their po...

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Detalles Bibliográficos
Autores principales: Bachran, Christopher, Morley, Thomas, Abdelazim, Suzanne, Fattah, Rasem J., Liu, Shihui, Leppla, Stephen H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Microbiology 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648902/
https://www.ncbi.nlm.nih.gov/pubmed/23631917
http://dx.doi.org/10.1128/mBio.00201-13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648902/
https://www.ncbi.nlm.nih.gov/pubmed/23631917
http://dx.doi.org/10.1128/mBio.00201-13

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