Cargando…

Anthrax Toxin-Mediated Delivery of the Pseudomonas Exotoxin A Enzymatic Domain to the Cytosol of Tumor Cells via Cleavable Ubiquitin Fusions

Anthrax toxin proteins from Bacillus anthracis constitute a highly efficient system for delivering cytotoxic enzymes to the cytosol of tumor cells. However, exogenous proteins delivered to the cytosol of cells are subject to ubiquitination on lysines and proteasomal degradation, which limit their po...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bachran, Christopher, Morley, Thomas, Abdelazim, Suzanne, Fattah, Rasem J., Liu, Shihui, Leppla, Stephen H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Microbiology 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3648902/ https://www.ncbi.nlm.nih.gov/pubmed/23631917 http://dx.doi.org/10.1128/mBio.00201-13

Ejemplares similares

Reductive Methylation and Mutation of an Anthrax Toxin Fusion Protein Modulates its Stability and Cytotoxicity
por: Bachran, Christopher, et al.
Publicado: (2014)

Tumor Targeting and Drug Delivery by Anthrax Toxin
por: Bachran, Christopher, et al.
Publicado: (2016)

Anti-tumor activity of anthrax toxin variants that form a functional translocation pore by intermolecular complementation
por: Liu, Shihui, et al.
Publicado: (2017)

Cytolethal distending toxin B as a cell-killing component of tumor-targeted anthrax toxin fusion proteins
por: Bachran, C, et al.
Publicado: (2014)

An anthrax toxin variant with an improved activity in tumor targeting
por: Wein, Alexander N., et al.
Publicado: (2015)

Anthrax Lethal Factor Cleaves Mouse Nlrp1b in Both Toxin-Sensitive and Toxin-Resistant Macrophages
por: Hellmich, Kristina A., et al.
Publicado: (2012)

Receptor palmitoylation and ubiquitination regulate anthrax toxin endocytosis
por: Abrami, Laurence, et al.
Publicado: (2006)

The Receptors that Mediate the Direct Lethality of Anthrax Toxin
por: Liu, Shihui, et al.
Publicado: (2012)

Role of N-Terminal Amino Acids in the Potency of Anthrax Lethal Factor
por: Gupta, Pradeep K., et al.
Publicado: (2008)

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome
por: Levinsohn, Jonathan L., et al.
Publicado: (2012)

Anthrax Edema Factor Toxicity Is Strongly Mediated by the N-end Rule
por: Leysath, Clinton E., et al.
Publicado: (2013)

Bacterial Exotoxins and the Inflammasome
por: Greaney, Allison J., et al.
Publicado: (2015)

Imaging of anthrax intoxication in mice reveals shared and individual functions of surface receptors CMG-2 and TEM-8 in cellular toxin entry
por: Merritt, Carly, et al.
Publicado: (2021)

Cellular and Physiological Effects of Anthrax Exotoxin and Its Relevance to Disease
por: Lowe, David E., et al.
Publicado: (2012)

Efficient Targeting of Head and Neck Squamous Cell Carcinoma by Systemic Administration of a Dual uPA and MMP-Activated Engineered Anthrax Toxin
por: Schafer, Jeffrey M., et al.
Publicado: (2011)

Anthrax toxin triggers endocytosis of its receptor via a lipid raft–mediated clathrin-dependent process
por: Abrami, Laurence, et al.
Publicado: (2003)

Anthrax Toxin Uptake by Primary Immune Cells as Determined with a Lethal Factor-β-Lactamase Fusion Protein
por: Hu, Haijing, et al.
Publicado: (2009)

Pseudomonas Exotoxin-Based Immunotoxins: Over Three Decades of Efforts on Targeting Cancer Cells With the Toxin
por: Havaei, Seyed Mehdi, et al.
Publicado: (2021)

Thermodynamic Stability Is a Strong Predictor for the Delivery of DARPins to the Cytosol via Anthrax Toxin
por: Becker, Lukas, et al.
Publicado: (2021)

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine and Human Osteosarcoma Cells
por: Mackowiak da Fonseca, Jonathan, et al.
Publicado: (2020)

Pseudomonas Exotoxin A Based Toxins Targeting Epidermal Growth Factor Receptor for the Treatment of Prostate Cancer
por: Fischer, Alexandra, et al.
Publicado: (2020)

Pseudomonas Exotoxin A: optimized by evolution for effective killing
por: Michalska, Marta, et al.
Publicado: (2015)

Targeting the membrane-anchored serine protease testisin with a novel engineered anthrax toxin prodrug to kill tumor cells and reduce tumor burden
por: Martin, Erik W., et al.
Publicado: (2015)

A Dominant-Negative Approach That Prevents Diphthamide Formation Confers Resistance to Pseudomonas Exotoxin A and Diphtheria Toxin
por: Roy, Vincent, et al.
Publicado: (2010)

Inhibitory Effects of a Reengineered Anthrax Toxin on Canine Oral Mucosal Melanomas
por: Nishiya, Adriana Tomoko, et al.
Publicado: (2020)

Anthrax Toxins Induce Shock in Rats by Depressed Cardiac Ventricular Function
por: Watson, Linley E., et al.
Publicado: (2007)

Susceptibility to Anthrax Lethal Toxin-Induced Rat Death Is Controlled by a Single Chromosome 10 Locus That Includes rNlrp1
por: Newman, Zachary L., et al.
Publicado: (2010)

Exotoxin S secreted by internalized Pseudomonas aeruginosa delays lytic host cell death
por: Kroken, Abby R., et al.
Publicado: (2022)

A pipeline to evaluate inhibitors of the Pseudomonas aeruginosa exotoxin U
por: Foulkes, Daniel M., et al.
Publicado: (2021)

DARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin
por: Becker, Lukas, et al.
Publicado: (2023)

Roles of Anthrax Toxin Receptor 2 in Anthrax Toxin Membrane Insertion and Pore Formation
por: Sun, Jianjun, et al.
Publicado: (2016)

Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems
por: Della Cristina, Pietro, et al.
Publicado: (2015)

Anthrax toxin takes charge
por: Dove, Alan W.
Publicado: (2003)

Anthrax toxin rafts into cells
por: Kurzchalia, Teymuras
Publicado: (2003)

The Ins and Outs of Anthrax Toxin
por: Friebe, Sarah, et al.
Publicado: (2016)

In Vitro Evaluation of Vegf-Pseudomonas Exotoxin: A Conjugated on Tumor Cells
por: Langari, Jahangir, et al.
Publicado: (2017)

Immunogenicity of Immunotoxins Containing Pseudomonas Exotoxin A: Causes, Consequences, and Mitigation
por: Mazor, Ronit, et al.
Publicado: (2020)

Mechanisms of Resistance to Immunotoxins Containing Pseudomonas Exotoxin A in Cancer Therapy
por: Dieffenbach, Michael, et al.
Publicado: (2020)

Anthrax edema toxin disrupts distinct steps in Rab11-dependent junctional transport
por: Guichard, Annabel, et al.
Publicado: (2017)

Community-Acquired Respiratory Distress Syndrome Toxin: Unique Exotoxin for M. pneumoniae
por: Su, Xiaoling, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_4k9ug88mmksj5mabfbo6ua35oq