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Label-Free Potentiometry for Detecting DNA Hybridization Using Peptide Nucleic Acid and DNA Probes

Peptide nucleic acid (PNA) has outstanding affinity over DNA for complementary nucleic acid sequences by forming a PNA-DNA heterodimer upon hybridization via Watson-Crick base-pairing. To verify whether PNA probes on an electrode surface enhance sensitivity for potentiometric DNA detection or not, w...

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Detalles Bibliográficos
Autores principales: Goda, Tatsuro, Singi, Ankit Balram, Maeda, Yasuhiro, Matsumoto, Akira, Torimura, Masaki, Aoki, Hiroshi, Miyahara, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649381/
https://www.ncbi.nlm.nih.gov/pubmed/23435052
http://dx.doi.org/10.3390/s130202267