Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay

BACKGROUND: Haploinsufficiency of SHANK3, due to either hemizygous gene deletion (termed 22q13 deletion syndrome or Phelan-McDermid syndrome) or to gene mutation, accounts for about 0.5% of the cases of autism spectrum disorder (ASD) and/or developmental delay, and there is evidence for a wider role...

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Detalles Bibliográficos
Autores principales: Bozdagi, Ozlem, Tavassoli, Teresa, Buxbaum, Joseph D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649942/
https://www.ncbi.nlm.nih.gov/pubmed/23621888
http://dx.doi.org/10.1186/2040-2392-4-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649942/
https://www.ncbi.nlm.nih.gov/pubmed/23621888
http://dx.doi.org/10.1186/2040-2392-4-9

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