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Insulin-like growth factor-1 rescues synaptic and motor deficits in a mouse model of autism and developmental delay
BACKGROUND: Haploinsufficiency of SHANK3, due to either hemizygous gene deletion (termed 22q13 deletion syndrome or Phelan-McDermid syndrome) or to gene mutation, accounts for about 0.5% of the cases of autism spectrum disorder (ASD) and/or developmental delay, and there is evidence for a wider role...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649942/ https://www.ncbi.nlm.nih.gov/pubmed/23621888 http://dx.doi.org/10.1186/2040-2392-4-9 |