The Specificity and Flexibility of L1 Reverse Transcription Priming at Imperfect T-Tracts

L1 retrotransposons have a prominent role in reshaping mammalian genomes. To replicate, the L1 ribonucleoprotein particle (RNP) first uses its endonuclease (EN) to nick the genomic DNA. The newly generated DNA end is subsequently used as a primer to initiate reverse transcription within the L1 RNA p...

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Detalles Bibliográficos
Autores principales: Monot, Clément, Kuciak, Monika, Viollet, Sébastien, Mir, Ashfaq Ali, Gabus, Caroline, Darlix, Jean-Luc, Cristofari, Gaël
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649969/
https://www.ncbi.nlm.nih.gov/pubmed/23675310
http://dx.doi.org/10.1371/journal.pgen.1003499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649969/
https://www.ncbi.nlm.nih.gov/pubmed/23675310
http://dx.doi.org/10.1371/journal.pgen.1003499

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