Duplication and Retention Biases of Essential and Non-Essential Genes Revealed by Systematic Knockdown Analyses

When a duplicate gene has no apparent loss-of-function phenotype, it is commonly considered that the phenotype has been masked as a result of functional redundancy with the remaining paralog. This is supported by indirect evidence showing that multi-copy genes show loss-of-function phenotypes less o...

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Detalles Bibliográficos
Autores principales: Woods, Shane, Coghlan, Avril, Rivers, David, Warnecke, Tobias, Jeffries, Sean J., Kwon, Taejoon, Rogers, Anthony, Hurst, Laurence D., Ahringer, Julie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649981/
https://www.ncbi.nlm.nih.gov/pubmed/23675306
http://dx.doi.org/10.1371/journal.pgen.1003330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649981/
https://www.ncbi.nlm.nih.gov/pubmed/23675306
http://dx.doi.org/10.1371/journal.pgen.1003330

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