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Duplication and Retention Biases of Essential and Non-Essential Genes Revealed by Systematic Knockdown Analyses
When a duplicate gene has no apparent loss-of-function phenotype, it is commonly considered that the phenotype has been masked as a result of functional redundancy with the remaining paralog. This is supported by indirect evidence showing that multi-copy genes show loss-of-function phenotypes less o...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3649981/ https://www.ncbi.nlm.nih.gov/pubmed/23675306 http://dx.doi.org/10.1371/journal.pgen.1003330 |