The EGF Repeat-Specific O-GlcNAc-Transferase Eogt Interacts with Notch Signaling and Pyrimidine Metabolism Pathways in Drosophila

The O-GlcNAc transferase Eogt modifies EGF repeats in proteins that transit the secretory pathway, including Dumpy and Notch. In this paper, we show that the Notch ligands Delta and Serrate are also substrates of Eogt, that mutation of a putative UDP-GlcNAc binding DXD motif greatly reduces enzyme a...

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Detalles Bibliográficos
Autores principales: Müller, Reto, Jenny, Andreas, Stanley, Pamela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650022/
https://www.ncbi.nlm.nih.gov/pubmed/23671640
http://dx.doi.org/10.1371/journal.pone.0062835

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650022/
https://www.ncbi.nlm.nih.gov/pubmed/23671640
http://dx.doi.org/10.1371/journal.pone.0062835

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