Aristaless-Related Homeobox Plays a Key Role in Hyperplasia of the Pancreas Islet α–Like Cells in Mice Deficient in Proglucagon-Derived Peptides

Defects in glucagon action can cause hyperplasia of islet α-cells, however, the underlying mechanisms remain largely to be elucidated. Mice homozygous for a glucagon-GFP knock-in allele (Gcg(gfp/gfp)) completely lack proglucagon-derived peptides and exhibit hyperplasia of GFP-positive α-like cells....

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Detalles Bibliográficos
Autores principales: Xu, Sai, Hayashi, Yoshitaka, Takagishi, Yoshiko, Itoh, Mariko, Murata, Yoshiharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650067/
https://www.ncbi.nlm.nih.gov/pubmed/23671715
http://dx.doi.org/10.1371/journal.pone.0064415

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650067/
https://www.ncbi.nlm.nih.gov/pubmed/23671715
http://dx.doi.org/10.1371/journal.pone.0064415

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