Expanding the Repertoire of Target Sites for Zinc Finger Nuclease-mediated Genome Modification

Recent studies have shown that zinc finger nucleases (ZFNs) are powerful reagents for making site-specific genomic modifications. The generic structure of these enzymes includes a ZF DNA-binding domain and nuclease domain (Fn) are separated by an amino acid “linker” and cut genomic DNA at sites that...

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Detalles Bibliográficos
Autores principales: Wilson, Kimberly A, McEwen, Abbye E, Pruett-Miller, Shondra M, Zhang, Jiuli, Kildebeck, Eric J, Porteus, Matthew H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650245/
https://www.ncbi.nlm.nih.gov/pubmed/23632390
http://dx.doi.org/10.1038/mtna.2013.13

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650245/
https://www.ncbi.nlm.nih.gov/pubmed/23632390
http://dx.doi.org/10.1038/mtna.2013.13

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