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Differential effects of norUDCA and UDCA in obstructive cholestasis in mice

BACKGROUND & AIMS: The quest for effective drugs to treat cholangiopathies led to the development of norUDCA previously shown to have potent choleretic effects and to heal cholangiopathy in Abcb4 knockout (Abcb4(−/−)) mice. Its mother compound UDCA had detrimental effects in common bile duct lig...

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Detalles Bibliográficos
Autores principales: Fickert, Peter, Pollheimer, Marion J., Silbert, Dagmar, Moustafa, Tarek, Halilbasic, Emina, Krones, Elisabeth, Durchschein, Franziska, Thüringer, Andrea, Zollner, Gernot, Denk, Helmut, Trauner, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650580/
https://www.ncbi.nlm.nih.gov/pubmed/23369794
http://dx.doi.org/10.1016/j.jhep.2013.01.026