Activating Mutations in Protein Tyrosine Phosphatase Ptpn11 (Shp2) Enhance Reactive Oxygen Species Production That Contributes to Myeloproliferative Disorder

Gain of function (GOF) mutations in protein tyrosine phosphatase Ptpn11 have been identified in childhood leukemias, and these mutations are sufficient to drive the development of myeloproliferative disorder and malignant leukemias in mice. However, the molecular mechanisms by which Ptpn11 mutations...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Dan, Zheng, Hong, Yu, Wen-Mei, Qu, Cheng-Kui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651249/
https://www.ncbi.nlm.nih.gov/pubmed/23675459
http://dx.doi.org/10.1371/journal.pone.0063152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651249/
https://www.ncbi.nlm.nih.gov/pubmed/23675459
http://dx.doi.org/10.1371/journal.pone.0063152

Ejemplares similares