Microglial activation decreases retention of the protease inhibitor saquinavir: implications for HIV treatment

BACKGROUND: Active HIV infection within the central nervous system (CNS) is confined primarily to microglia. The glial cell compartment acts as a viral reservoir behind the blood-brain barrier. It provides an additional roadblock to effective pharmacological treatment via expression of multiple drug...

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Detalles Bibliográficos
Autores principales: Dallas, Shannon, Block, Michelle L, Thompson, Deborah M, Bonini, Marcelo G, Ronaldson, Patrick T, Bendayan, Reina, Miller, David S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651327/
https://www.ncbi.nlm.nih.gov/pubmed/23642074
http://dx.doi.org/10.1186/1742-2094-10-58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651327/
https://www.ncbi.nlm.nih.gov/pubmed/23642074
http://dx.doi.org/10.1186/1742-2094-10-58

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