Clinical trial simulation to evaluate power to compare the antiviral effectiveness of two hepatitis C protease inhibitors using nonlinear mixed effect models: a viral kinetic approach

BACKGROUND: Models of hepatitis C virus (HCV) kinetics are increasingly used to estimate and to compare in vivo drug’s antiviral effectiveness of new potent anti-HCV agents. Viral kinetic parameters can be estimated using non-linear mixed effect models (NLMEM). Here we aimed to evaluate the performa...

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Detalles Bibliográficos
Autores principales: Laouénan, Cédric, Guedj, Jeremie, Mentré, France
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651343/
https://www.ncbi.nlm.nih.gov/pubmed/23617810
http://dx.doi.org/10.1186/1471-2288-13-60

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651343/
https://www.ncbi.nlm.nih.gov/pubmed/23617810
http://dx.doi.org/10.1186/1471-2288-13-60

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