Cargando…
CoDP: predicting the impact of unclassified genetic variants in MSH6 by the combination of different properties of the protein
BACKGROUND: Lynch syndrome is a hereditary cancer predisposition syndrome caused by a mutation in one of the DNA mismatch repair (MMR) genes. About 24% of the mutations identified in Lynch syndrome are missense substitutions and the frequency of missense variants in MSH6 is the highest amongst these...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2013
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651391/ https://www.ncbi.nlm.nih.gov/pubmed/23621914 http://dx.doi.org/10.1186/1423-0127-20-25 |