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CoDP: predicting the impact of unclassified genetic variants in MSH6 by the combination of different properties of the protein

BACKGROUND: Lynch syndrome is a hereditary cancer predisposition syndrome caused by a mutation in one of the DNA mismatch repair (MMR) genes. About 24% of the mutations identified in Lynch syndrome are missense substitutions and the frequency of missense variants in MSH6 is the highest amongst these...

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Detalles Bibliográficos
Autores principales:	Terui, Hiroko, Akagi, Kiwamu, Kawame, Hiroshi, Yura, Kei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651391/ https://www.ncbi.nlm.nih.gov/pubmed/23621914 http://dx.doi.org/10.1186/1423-0127-20-25

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