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Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL

Bacterial mechanosensitive channels are some of the largest pores in nature. In particular, MscL, with a pore diameter > 25 Å, allows passage of large organic ions and small proteins. Functional MscL reconstitution into lipids has been proposed for applications in vesicular-based drug release. He...

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Detalles Bibliográficos
Autores principales: Doerner, Julia F., Febvay, Sebastien, Clapham, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651673/
https://www.ncbi.nlm.nih.gov/pubmed/22871809
http://dx.doi.org/10.1038/ncomms1999