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Determination of the optimal tubulin isotype target as a method for the development of individualized cancer chemotherapy

BACKGROUND: As microtubules are essential for cell growth and division, its constituent protein β-tubulin has been a popular target for various treatments, including cancer chemotherapy. There are several isotypes of human β-tubulin and each type of cell expresses its characteristic distribution of...

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Detalles Bibliográficos
Autores principales: Ravanbakhsh, Siamak, Gajewski, Melissa, Greiner, Russell, Tuszynski, Jack A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651705/
https://www.ncbi.nlm.nih.gov/pubmed/23634782
http://dx.doi.org/10.1186/1742-4682-10-29