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Phospholipase C-related but catalytically inactive protein modulates pain behavior in a neuropathic pain model in mice

BACKGROUND: An inositol 1,4,5-trisphosphate binding protein, comprising 2 isoforms termed PRIP-1 and PRIP-2, was identified as a novel modulator for GABA(A) receptor trafficking. It has been reported that naive PRIP-1 knockout mice have hyperalgesic responses. FINDINGS: To determine the involvement...

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Detalles Bibliográficos
Autores principales: Kitayama, Tomoya, Morita, Katsuya, Sultana, Rizia, Kikushige, Nami, Mgita, Keisuke, Ueno, Shinya, Hirata, Masato, Kanematsu, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651726/
https://www.ncbi.nlm.nih.gov/pubmed/23639135
http://dx.doi.org/10.1186/1744-8069-9-23