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DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair

Homologous recombination (HR) and nonhomologous end-joining (NHEJ) are two distinct DNA double-strand break (DSB) repair pathways. Here we report that DNA-dependent protein kinase (DNA-PK), the core component of NHEJ, partnering with DNA-damage checkpoint kinases ataxia telangiectasia mutated (ATM)...

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Detalles Bibliográficos
Autores principales:	Serrano, Moises A., Li, Zhengke, Dangeti, Mohan, Musich, Phillip R., Patrick, Steve, Roginskaya, Marina, Cartwright, Brian, Zou, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3651755/ https://www.ncbi.nlm.nih.gov/pubmed/22797063 http://dx.doi.org/10.1038/onc.2012.257

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